Assuming it did once work okay, then sometimes the c:\windows\setscan.ini file which is used by the Canon TWAIN drivers becomes corrupted and this causes the Canon TWAIN driver to stop working with EzeScan.
Try the following:
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Close EzeScan
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Rename setscan.ini to setscan.old
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Reload EzeScan and run a job (that uses this scanner)
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You will get a prompt for a scanner model, select your scanner in the drop down list.
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Test that the job runs ok.
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Load EzeScan and try the job again.
Contact EzeScan support if the issue is still occurring.